Irreversible EGFR Inhibitor EKB-569 Targets Low-LET γ-Radiation-Triggered Rel Orchestration and Potentiates Cell Death in Squamous Cell Carcinoma

EKB-569 (Pelitinib), an irreversible EGFR tyrosine kinase inhibitor has shown potential therapeutic efficiency in solid tumors. However, cell-killing potential in combination with radiotherapy and its underlying molecular orchestration remain to be explored. The objective of this study was to determ...

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Bibliographische Detailangaben
Hauptverfasser: Aravindan, Natarajan, Thomas, Charles R., Aravindan, Sheeja, Mohan, Aswathi S., Veeraraghavan, Jamunarani, Natarajan, Mohan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2011
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3248439/
https://ncbi.nlm.nih.gov/pubmed/22242139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0029705
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