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Drosophila and mammalian models uncover a role for the myoblast fusion gene TANC1 in rhabdomyosarcoma
Rhabdomyosarcoma (RMS) is a malignancy of muscle myoblasts, which fail to exit the cell cycle, resist terminal differentiation, and are blocked from fusing into syncytial skeletal muscle. In some patients, RMS is caused by a translocation that generates the fusion oncoprotein PAX-FOXO1, but the unde...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3248305/ https://ncbi.nlm.nih.gov/pubmed/22182840 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI59877 |
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