Angiotensin receptor blockade attenuates cigarette smoke–induced lung injury and rescues lung architecture in mice

Chronic obstructive pulmonary disease (COPD) is a prevalent smoking-related disease for which no disease-altering therapies currently exist. As dysregulated TGF-β signaling associates with lung pathology in patients with COPD and in animal models of lung injury induced by chronic exposure to cigaret...

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Main Authors: Podowski, Megan, Calvi, Carla, Metzger, Shana, Misono, Kaori, Poonyagariyagorn, Hataya, Lopez-Mercado, Armando, Ku, Therese, Lauer, Thomas, McGrath-Morrow, Sharon, Berger, Alan, Cheadle, Christopher, Tuder, Rubin, Dietz, Harry C., Mitzner, Wayne, Wise, Robert, Neptune, Enid
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2011
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3248282/
https://ncbi.nlm.nih.gov/pubmed/22182843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI46215
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