Pharmacokinetics and pharmacodynamics following maintenance doses of prasugrel and clopidogrel in Chinese carriers of CYP2C19 variants

AIMS: This open-label, two-period, randomized, crossover study was designed to determine the effect of CYP2C19 reduced function variants on exposure to active metabolites of, and platelet response to, prasugrel and clopidogrel. METHODS: Ninety healthy Chinese subjects, stratified by CYP2C19 phenotyp...

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Bibliographische Detailangaben
Hauptverfasser: Kelly, Ronan P, Close, Sandra L, Farid, Nagy A, Winters, Kenneth J, Shen, Lei, Natanegara, Fanni, Jakubowski, Joseph A, Ho, Mary, Walker, Joseph R, Small, David S
Format: Artigo
Sprache:Inglês
Veröffentlicht: Blackwell Science Inc 2012
Schlagworte:
Pharmacokinetic Dynamic Relationships
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3248259/
https://ncbi.nlm.nih.gov/pubmed/21689142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2011.04049.x
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