Methicillin-resistant Staphylococcus aureus (MRSA) Pyruvate Kinase as a Target for Bis-indole Alkaloids with Antibacterial Activities

Novel classes of antimicrobials are needed to address the emergence of multidrug-resistant bacteria such as methicillin-resistant Staphylococcus aureus (MRSA). We have recently identified pyruvate kinase (PK) as a potential novel drug target based upon it being an essential hub in the MRSA interacto...

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Auteurs principaux: Zoraghi, Roya, Worrall, Liam, See, Raymond H., Strangman, Wendy, Popplewell, Wendy L., Gong, Huansheng, Samaai, Toufiek, Swayze, Richard D., Kaur, Sukhbir, Vuckovic, Marija, Finlay, B. Brett, Brunham, Robert C., McMaster, William R., Davies-Coleman, Michael T., Strynadka, Natalie C., Andersen, Raymond J., Reiner, Neil E.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2011
Sujets:
Microbiology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3248012/
https://ncbi.nlm.nih.gov/pubmed/22030393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.289033
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