Identification of a cAMP-response Element in the Regulator of G-protein Signaling-2 (RGS2) Promoter as a Key Cis-regulatory Element for RGS2 Transcriptional Regulation by Angiotensin II in Cultured Vascular Smooth Muscles

Mice deficient in regulator of G-protein signaling-2 (RGS2) have severe hypertension, and RGS2 genetic variations occur in hypertensive humans. A potentially important negative feedback loop in blood pressure homeostasis is that angiotensin II (Ang II) increases vascular smooth muscle cell (VSMC) RG...

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Detalhes bibliográficos
Main Authors: Xie, Zhongwen, Liu, Dexiang, Liu, Shu, Calderon, Lindsay, Zhao, Guogang, Turk, John, Guo, Zhenheng
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Gene Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3247950/
https://ncbi.nlm.nih.gov/pubmed/22057271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.265462
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