Development of replication-defective lymphocytic choriomeningitis virus vectors for the induction of potent CD8(+) T cell immunity

Lymphocytic choriomeningitis virus (LCMV) exhibits natural tropism for dendritic cells and represents the prototypic infection that elicits protective CD8(+) T cell (cytotoxic T lymphocyte (CTL)) immunity. Here we have harnessed the immunobiology of this arenavirus for vaccine delivery. By using pro...

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Hauptverfasser: Flatz, Lukas, Hegazy, Ahmed N, Bergthaler, Andreas, Verschoor, Admar, Claus, Christina, Fernandez, Marylise, Gattinoni, Luca, Johnson, Susan, Kreppel, Florian, Kochanek, Stefan, van den Broek, Maries, Radbruch, Andreas, Lévy, Frédéric, Lambert, Paul-Henri, Siegrist, Claire-Anne, Restifo, Nicholas P, Löhning, Max, Ochsenbein, Adrian F, Nabel, Gary J, Pinschewer, Daniel D
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3247638/
https://ncbi.nlm.nih.gov/pubmed/20139992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2104
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