Sildenafil restores cognitive function without affecting β-amyloid burden in a mouse model of Alzheimer's disease

BACKGROUND AND PURPOSE: Inhibitors of phosphodiesterase 5 (PDE5) affect signalling pathways by elevating cGMP, which is a second messenger involved in processes of neuroplasticity. In the present study, the effects of the PDE5 inhibitor, sildenafil, on the pathological features of Alzheimer's d...

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Detalhes bibliográficos
Main Authors: Cuadrado-Tejedor, M, Hervias, I, Ricobaraza, A, Puerta, E, Pérez-Roldán, JM, García-Barroso, C, Franco, R, Aguirre, N, García-Osta, A
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2011
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3246665/
https://ncbi.nlm.nih.gov/pubmed/21627640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2011.01517.x
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