Sildenafil restores cognitive function without affecting β-amyloid burden in a mouse model of Alzheimer's disease

BACKGROUND AND PURPOSE: Inhibitors of phosphodiesterase 5 (PDE5) affect signalling pathways by elevating cGMP, which is a second messenger involved in processes of neuroplasticity. In the present study, the effects of the PDE5 inhibitor, sildenafil, on the pathological features of Alzheimer's d...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Cuadrado-Tejedor, M, Hervias, I, Ricobaraza, A, Puerta, E, Pérez-Roldán, JM, García-Barroso, C, Franco, R, Aguirre, N, García-Osta, A
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Blackwell Publishing Ltd 2011
Aiheet:
Research Papers
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3246665/
https://ncbi.nlm.nih.gov/pubmed/21627640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2011.01517.x
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