Glutamate Transporter GLT-1 Upregulation Attenuates Visceral Nociception and Hyperalgesia via Spinal Mechanisms Not Related to Anti-Inflammatory or Probiotic Effects

Visceral pain is the most common reason for physician visits in US. Glutamate is the major excitatory neurotransmitter and mediates visceral nociceptive neuro-transmission and hypersensitivity. Removal of extracellular glutamate is predominantly mediated by glial glutamate transporter-1 (GLT-1). The...

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Main Authors: Lin, Y., Roman, K., Foust, K. D., Kaspar, B. K., Bailey, M. T., Stephens, R. L.
Format: Artigo
Jezik:Inglês
Izdano: Hindawi Publishing Corporation 2011
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3246297/
https://ncbi.nlm.nih.gov/pubmed/22220274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2011/507029
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