Role for mTOR Signaling and Neuronal Activity in Morphine-Induced Adaptations in Ventral Tegmental Area Dopamine Neurons

While the abuse of opiate drugs continues to rise, the neuroadaptations that occur with long-term drug exposure remain poorly understood. We describe here a series of chronic morphine-induced adaptations in ventral tegmental area (VTA) dopamine neurons, which are mediated via downregulation of AKT-m...

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Huvudupphovsmän: Mazei-Robison, M.S., Koo, J.W., Friedman, A., Lansink, C.S., Robison, A.J., Vinish, M., Krishnan, V., Kim, S., Siuta, M.A., Galli, M. A., Niswender, K.D., Appasani, R., Horvath, M.C., Neve, R.L., Worley, P.F., Snyder, S.H., Hurd, Y.L., Cheer, J.F., Han, M.H., Russo, S.J., Nestler, E.J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2011
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3246191/
https://ncbi.nlm.nih.gov/pubmed/22196333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2011.10.012
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