Environmental enrichment decreases GABAergic inhibition and improves cognitive abilities, synaptic plasticity, and visual functions in a mouse model of Down syndrome

Down syndrome (DS) is the most common genetic disorder associated with mental retardation. It has been repeatedly shown that Ts65Dn mice, the prime animal model for DS, have severe cognitive and neural plasticity defects due to excessive inhibition. We report that increasing sensory-motor stimulatio...

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Autori principali: Begenisic, Tatjana, Spolidoro, Maria, Braschi, Chiara, Baroncelli, Laura, Milanese, Marco, Pietra, Gianluca, Fabbri, Maria E., Bonanno, Giambattista, Cioni, Giovanni, Maffei, Lamberto, Sale, Alessandro
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2011
Soggetti:
Neuroscience
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3245647/
https://ncbi.nlm.nih.gov/pubmed/22207837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2011.00029
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