Environmental enrichment decreases GABAergic inhibition and improves cognitive abilities, synaptic plasticity, and visual functions in a mouse model of Down syndrome

Down syndrome (DS) is the most common genetic disorder associated with mental retardation. It has been repeatedly shown that Ts65Dn mice, the prime animal model for DS, have severe cognitive and neural plasticity defects due to excessive inhibition. We report that increasing sensory-motor stimulatio...

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Hlavní autoři: Begenisic, Tatjana, Spolidoro, Maria, Braschi, Chiara, Baroncelli, Laura, Milanese, Marco, Pietra, Gianluca, Fabbri, Maria E., Bonanno, Giambattista, Cioni, Giovanni, Maffei, Lamberto, Sale, Alessandro
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2011
Témata:
Neuroscience
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3245647/
https://ncbi.nlm.nih.gov/pubmed/22207837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2011.00029
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