Lamin B receptor (LBR) regulates the growth and maturation of myeloid progenitors via its sterol reductase domain: Implications for cholesterol biosynthesis in regulating myelopoiesis

Lamin B receptor (LBR) is a bifunctional nuclear membrane protein with N-terminal lamin B and chromatin binding domains plus a C-terminal sterol Δ14 reductase domain. LBR expression increases during neutrophil differentiation and deficient expression disrupts neutrophil nuclear lobulation characteri...

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Main Authors: Subramanian, Gayathri, Chaudhury, Pulkit, Malu, Krishnakumar, Fowler, Samantha, Manmode, Rahul, Gotur, Deepali, Zwerger, Monika, Ryan, David, Roberti, Rita, Gaines, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3244548/
https://ncbi.nlm.nih.gov/pubmed/22140257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1003804
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