Kynurenine 3-monooxygenase polymorphisms: relevance for kynurenic acid synthesis in patients with schizophrenia and healthy controls

BACKGROUND: Patients with schizophrenia show increased brain and cerebrospinal fluid (CSF) concentrations of the endogenous N-methyl-d-aspartate receptor antagonist kynurenic acid (KYNA). This compound is an end-metabolite of the kynurenine pathway, and its formation indirectly depends on the activi...

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Main Authors: Holtze, Maria, Saetre, Peter, Engberg, Göran, Schwieler, Lilly, Werge, Thomas, Andreassen, Ole A., Hall, Håkan, Terenius, Lars, Agartz, Ingrid, Jönsson, Erik G., Schalling, Martin, Erhardt, Sophie
Format: Artigo
Jezik:Inglês
Izdano: Canadian Medical Association 2012
Teme:
Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3244499/
https://ncbi.nlm.nih.gov/pubmed/21693093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1503/jpn.100175
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