Peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α) regulates triglyceride metabolism by activation of the nuclear receptor FXR

Peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α) has been shown to regulate adaptive thermogenesis and glucose metabolism. Here we show that PGC-1α regulates triglyceride metabolism through both farnesoid X receptor (FXR)-dependent and -independent pathways. PGC-1α increases FXR...

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Publié dans:	Genes Dev
Auteurs principaux:	Zhang, Yanqiao, Castellani, Lawrence W., Sinal, Christopher J., Gonzalez, Frank J., Edwards, Peter A.
Format:	Artigo
Langue:	Inglês
Publié:	Cold Spring Harbor Laboratory Press 2004
Sujets:	Research Papers
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC324422/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14729567/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.1138104
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