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PBEF exerts a neuronal protection through its enzymatic activity and the reduction of mitochondrial dysfunction in in vitro ischemic models
Pre-B-Cell Colony-Enhancing Factor (PBEF) is known as a rate-limiting enzyme that converts nicotinamide (NAM) to NMN in the salvage pathway of mammalian NAD(+) biosynthesis. Previously we found PBEF is exclusively expressed in neurons in the mouse brain; heterozygous PBEF knockout (Pbef(+/−)) mice h...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2011
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3243794/ https://ncbi.nlm.nih.gov/pubmed/22044451 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2011.07566.x |
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