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Limiting replication initiation factors execute the temporal programme of origin firing in budding yeast

Eukaryotic chromosomes are replicated from multiple origins that initiate throughout the S-phase of the cell cycle. Why all origins do not fire simultaneously at the beginning of S-phase is not known, but two kinase activities, cyclin-dependent kinase (CDK) and Dbf4-dependent kinase (DDK), are conti...

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Detalhes bibliográficos
Main Authors: Mantiero, Davide, Mackenzie, Amanda, Donaldson, Anne, Zegerman, Philip
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3243606/
https://ncbi.nlm.nih.gov/pubmed/22081107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.404
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