The MicroRNA 15a/16–1 Cluster Down-regulates Protein Repair Isoaspartyl Methyltransferase in Hepatoma Cells: IMPLICATIONS FOR APOPTOSIS REGULATION

Asparaginyl deamidation, a spontaneous protein post-biosynthetic modification, determines isoaspartyl formation and structure-function impairment. The isoaspartyl protein carboxyl-O-methyltransferase (PCMT1; EC 2.1.1.77) catalyzes the repair of the isopeptide bonds at isoaspartyl sites, preventing d...

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Detalhes bibliográficos
Main Authors: Sambri, Irene, Capasso, Rosanna, Pucci, Piero, Perna, Alessandra F., Ingrosso, Diego
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3243558/
https://ncbi.nlm.nih.gov/pubmed/22033921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.290437
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