Human Lipooligosaccharide IGG That Prevents Endemic Meningococcal Disease Recognizes an Internal Lacto-N-neotetraose Structure

Antibodies that initiate complement-mediated killing of Neisseria meningitidis as they enter the bloodstream from the oropharynx protect against disseminated disease. Human IgGs that bind the neisserial L7 lipooligosaccharide (LOS) are bactericidal for L3,7 and L2,4 meningococci in the presence of h...

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Autori principali: Cheng, Hui, Yang, Zhijie, Estabrook, Michele M., John, Constance M., Jarvis, Gary A., McLaughlin, Stephanie, Griffiss, J. McLeod
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2011
Soggetti:
Immunology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3243514/
https://ncbi.nlm.nih.gov/pubmed/22027827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.291583
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