Drug−disease interaction: Crohn's disease elevates verapamil plasma concentrations but reduces response to the drug proportional to disease activity

AIM: Inflammation is involved in the pathogenesis of cardiovascular diseases that includes reduced response to pharmacotherapy due to altered pharmacokinetics and pharmacodynamics. It is not known if these effects exist in general in all inflammatory conditions. It also remains unknown whether in a...

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Autores principales: Sanaee, Forough, Clements, John D, Waugh, Alistair W G, Fedorak, Richard N, Lewanczuk, Richard, Jamali, Fakhreddin
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Science Inc 2011
Materias:
Pharmacokinetic Dynamic Relationships
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3243013/
https://ncbi.nlm.nih.gov/pubmed/21592185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2011.04019.x
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