Farnesol-Induced Apoptosis in Candida albicans Is Mediated by Cdr1-p Extrusion and Depletion of Intracellular Glutathione

Farnesol is a key derivative in the sterol biosynthesis pathway in eukaryotic cells previously identified as a quorum sensing molecule in the human fungal pathogen Candida albicans. Recently, we demonstrated that above threshold concentrations, farnesol is capable of triggering apoptosis in C. albic...

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Detalhes bibliográficos
Main Authors: Zhu, Jingsong, Krom, Bastiaan P., Sanglard, Dominique, Intapa, Chaidan, Dawson, Clinton C., Peters, Brian M., Shirtliff, Mark E., Jabra-Rizk, Mary Ann
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3242750/
https://ncbi.nlm.nih.gov/pubmed/22205973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0028830
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