ATRA-induced upregulation of Beclin 1 prolongs the life span of differentiated acute promyelocytic leukemia cells

Acute promyelocytic leukemia (APL) results from a blockade of granulocyte differentiation at the promyelocytic stage. All-trans retinoic acid (ATRA) induces clinical remission in APL patients by enhancing the rapid differentiation of APL cells and the clearance of PML-RARα, APL's hallmark oncop...

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Bibliografiske detaljer
Main Authors: Trocoli, Aurore, Mathieu, Julie, Priault, Muriel, Reiffers, Josy, Souquere, Sylvie, Pierron, Gérard, Besançon, Françoise, Djavaheri-Mergny, Mojgan
Format: Artigo
Sprog:Inglês
Udgivet: Landes Bioscience 2011
Fag:
Translational Brief Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3242613/
https://ncbi.nlm.nih.gov/pubmed/21691148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.7.10.16623
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