Networks link antigenic and receptor-binding sites of influenza hemagglutinin: Mechanistic insight into fitter strain propagation

Influenza viral passaging through pre-vaccinated mice shows that emergent antigenic site mutations on the viral hemagglutinin (HA) impact host receptor-binding affinity and, therefore, the evolution of fitter influenza strains. To understand this phenomenon, we computed the Significant Interactions...

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Hlavní autoři: Soundararajan, Venkataramanan, Zheng, Shu, Patel, Neel, Warnock, Ken, Raman, Rahul, Wilson, Ian A., Raguram, S., Sasisekharan, V., Sasisekharan, Ram
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2011
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3242012/
https://ncbi.nlm.nih.gov/pubmed/22355715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep00200
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