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Mechanisms involved in enhancement of the expression and function of aggrecanases by hyaluronan oligosaccharides

OBJECTIVE: Small hyaluronan (HA) oligosaccharides serve as competitive receptor antagonists to displace HA from the cell surface and induce cell signaling events. In articular chondrocytes this cell signaling is mediated by the HA receptor CD44 and induces stimulation of genes involved in matrix deg...

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Bibliografiske detaljer
Main Authors: Ariyoshi, Wataru, Takahashi, Nobunori, Hida, Daisuke, Knudson, Cheryl B., Knudson, Warren
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3241893/
https://ncbi.nlm.nih.gov/pubmed/21905012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.33329
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