Novel N-Methylated 8-Oxoisoguanines from Pacific Sponges with Diverse Neuroactivities

Marine organisms have yielded a variety of metabolites with neuropharmacological applications. Here we describe the isolation and pharmacological characterization of four novel, neurologically active purines 1–4, isolated from Haplosclerida sponges collected in the Republic of Palau. The structures...

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Autori principali: Sakurada, Tsuyoshi, Gill, Martin B., Frausto, Shanti, Copits, Bryan, Noguchi, Keiichi, Shimamoto, Keiko, Swanson, Geoffrey T., Sakai, Ryuichi
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3241477/
https://ncbi.nlm.nih.gov/pubmed/20681583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm100490m
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