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HIF-1 Regulates Iron Homeostasis in Caenorhabditis elegans by Activation and Inhibition of Genes Involved in Iron Uptake and Storage

Caenorhabditis elegans ftn-1 and ftn-2, which encode the iron-storage protein ferritin, are transcriptionally inhibited during iron deficiency in intestine. Intestinal specific transcription is dependent on binding of ELT-2 to GATA binding sites in an iron-dependent enhancer (IDE) located in ftn-1 a...

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Bibliografiske detaljer
Main Authors: Romney, Steven Joshua, Newman, Ben S., Thacker, Colin, Leibold, Elizabeth A.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3240588/
https://ncbi.nlm.nih.gov/pubmed/22194696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002394
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