Microglia use multiple mechanisms to mediate interactions with vitronectin; non-essential roles for the highly-expressed αvβ3 and αvβ5 integrins

BACKGROUND: As the primary resident immune cells, microglia play a central role in regulating inflammatory processes in the CNS. The extracellular matrix (ECM) protein vitronectin promotes microglial activation, switching microglia into an activated phenotype. We have shown previously that microglia...

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Main Authors: Welser-Alves, Jennifer V, Boroujerdi, Amin, Tigges, Ulrich, Milner, Richard
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2011
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3239846/
https://ncbi.nlm.nih.gov/pubmed/22074485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-8-157
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