The acute inflammatory response to intranigral α-synuclein differs significantly from intranigral lipopolysaccharide and is exacerbated by peripheral inflammation

BACKGROUND: Activated microglia are a feature of the host response to neurodegeneration in Parkinson's disease (PD) and are thought to contribute to disease progression. Recent evidence suggests that extracellular α-synuclein (eSNCA) may play an important role in the pathogenesis of PD and that...

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Autori principali: Couch, Yvonne, Alvarez-Erviti, Lydia, Sibson, Nicola R, Wood, Matthew JA, Anthony, Daniel C
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2011
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3239418/
https://ncbi.nlm.nih.gov/pubmed/22122884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-8-166
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