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Targeting HIV-1 gp41-induced Fusion and Pathogenesis for Anti-viral Therapy

HIV gp41 is a metastable protein whose native conformation is maintained in the form of a heterodimer with gp120. The non-covalently associated gp41/gp120 complex forms a trimer on the virus surface. As gp120 engages with HIV’s receptor, CD4, and coreceptor, CXCR4 or CCR5, gp41 undergoes several con...

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Hlavní autoři: Garg, Himanshu, Viard, Mathias, Jacobs, Amy, Blumenthal, Robert
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3238677/
https://ncbi.nlm.nih.gov/pubmed/22044225
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