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Targeting HIV-1 gp41-induced Fusion and Pathogenesis for Anti-viral Therapy

HIV gp41 is a metastable protein whose native conformation is maintained in the form of a heterodimer with gp120. The non-covalently associated gp41/gp120 complex forms a trimer on the virus surface. As gp120 engages with HIV’s receptor, CD4, and coreceptor, CXCR4 or CCR5, gp41 undergoes several con...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Garg, Himanshu, Viard, Mathias, Jacobs, Amy, Blumenthal, Robert
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3238677/
https://ncbi.nlm.nih.gov/pubmed/22044225
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