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Early Changes in the Apparent Diffusion Coefficient (ADC) in a Mouse Model of Sandhoff’s Disease Occur Prior to Disease Symptoms and Behavioral Deficits
Sandhoff’s disease is a lysosomal storage disease in which the ganglioside, GM2, accumulates in lysosomes. It has been reported that MRI cannot detect abnormalities in spin echo images in clinically pre-symptomatic Sandhoff’s disease patients. Because one of the results of GM2 accumulation is cell s...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3238566/ https://ncbi.nlm.nih.gov/pubmed/19780154 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mrm.22138 |
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