Chimeric Alphavirus Vaccine Candidates Protect Mice from Intranasal Challenge with Western Equine Encephalitis Virus

We developed two types of chimeric Sindbis virus (SINV)/western equine encephalitis virus (WEEV) alphaviruses to investigate their potential use as live virus vaccines against WEE. The first-generation vaccine candidate, SIN/CO92, was derived from structural protein genes of WEEV strain CO92-1356, a...

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Main Authors: Atasheva, Svetlana, Wang, Eryu, Adams, A. Paige, Plante, Kenneth S., Ni, Sai, Taylor, Katherine, Miller, Mary E., Frolov, Ilya, Weaver, Scott C.
Format: Artigo
Jezik:Inglês
Izdano: 2009
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3238384/
https://ncbi.nlm.nih.gov/pubmed/19446595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2009.05.011
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