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Cloning and sequencing of the pertussis toxin genes: operon structure and gene duplication.

Pertussis toxin, a protein composed of five different subunits (S1, S2, S3, S4, and S5), is the major virulence factor of Bordetella pertussis. We have cloned and sequenced a DNA fragment of 4.7 kilobases that contains the genes coding for the five subunits. The genes are clustered within 3.2 kiloba...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Nicosia, A, Perugini, M, Franzini, C, Casagli, M C, Borri, M G, Antoni, G, Almoni, M, Neri, P, Ratti, G, Rappuoli, R
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1986
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC323795/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2873570/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.83.13.4631
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