Dual inhibition of Tumor Energy Pathway by 2-deoxy glucose and metformin Is Effective Against a Broad Spectrum of Preclinical Cancer Models

Tumor cell proliferation requires both growth signals and sufficient cellular bioenergetics.The AMP-activated kinase (AMPK) pathway appears dominant over the oncogenic signaling pathway suppressing cell proliferation. This study investigated the preclinical efficacy of targeting the tumor bioenerget...

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Main Authors: Cheong, Jae-Ho, Park, Eun Sung, Liang, Jiyong, Dennison, Jennifer B, Tsavachidou, Dimitra, Nguyen-Charles, Catherine, Cheng, Kwai Wa, Hall, Hassan, Zhang, Dong, Lu, Yiling, Ravoori, Murali, Kundra, Vikas, Ajani, Jaffer, Lee, Ju-Seog, Hong, Waun Ki, Mills, Gordon B
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3237863/
https://ncbi.nlm.nih.gov/pubmed/21992792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-11-0497
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