Presence and formation of codeine and morphine in the rat.

Endogenous codeine and morphine were identified in rat brain by immunological determination following HPLC. To demonstrate occurrence of a biosynthetic pathway to morphine in mammals similar to that used by the poppy plant, (+)-salutaridine, (-)-thebaine, and (-)-codeine were administered to rats in...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Donnerer, J, Oka, K, Brossi, A, Rice, K C, Spector, S
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1986
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC323775/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3459191/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.83.12.4566
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