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Acquisition of resistance towards HYD1 correlates with a reduction in cleaved alpha 4 integrin expression and a compromised CAM-DR phenotype

We recently reported that the β1 integrin antagonist referred to as HYD1 induces necrotic cell death in myeloma cell lines as a single agent using in vitro and in vivo models. In this report we sought to delineate the determinants of sensitivity and resistance towards HYD1 induced cell death. To thi...

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Autors principals: Emmons, Michael F., Gebhard, Anthony W., Nair, Rajesh R., Baz, Rachid, McLaughlin, Mark, Cress, Anne E., Hazlehurst, Lori A.
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3237739/
https://ncbi.nlm.nih.gov/pubmed/21980133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-11-0149
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