Long Term Stabilization of Expanding Aortic Aneurysms by a Short Course of Cyclosporine A through Transforming Growth Factor-Beta Induction

Abdominal aortic aneurysms (AAAs) expand as a consequence of extracellular matrix destruction, and vascular smooth muscle cell (VSMC) depletion. Transforming growth factor (TGF)-beta 1 overexpression stabilizes expanding AAAs in rat. Cyclosporine A (CsA) promotes tissue accumulation and induces TGF...

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Detalhes bibliográficos
Main Authors: Dai, Jianping, Michineau, Stéphanie, Franck, Grégory, Desgranges, Pascal, Becquemin, Jean-Pierre, Gervais, Marianne, Allaire, Eric
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3237613/
https://ncbi.nlm.nih.gov/pubmed/22194945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0028903
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