Disruption of TGF-β Signaling Improves Ocular Surface Epithelial Disease in Experimental Autoimmune Keratoconjunctivitis Sicca

BACKGROUND: TGF-β is a pleiotropic cytokine that can have pro- or anti-inflammatory effects depending on the context. Elevated levels of bioactive TGF-β1 in tears and elevated TGF-β1mRNA transcripts in conjunctiva and minor salivary glands of human Sjögren's Syndrome patients has also been repo...

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Main Authors: De Paiva, Cintia S., Volpe, Eugene A., Gandhi, Niral B., Zhang, Xiaobo, Zheng, Xiaofen, Pitcher, John D., Farley, William J., Stern, Michael E., Niederkorn, Jerry Y., Li, De-Quan, Flavell, Richard A., Pflugfelder, Stephen C.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2011
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3237576/
https://ncbi.nlm.nih.gov/pubmed/22194977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0029017
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