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Structural Constraints on the Covariance Matrix Derived from Multiple Aligned Protein Sequences

Residue contact predictions were calculated based on the mutual information observed between pairs of positions in large multiple protein sequence alignments. Where previously only the statistical properties of these data have been considered important, we introduce new measures to impose constraint...

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Autors principals: Taylor, William R., Sadowski, Michael I.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3237328/
https://ncbi.nlm.nih.gov/pubmed/22194819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0028265
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