Dominant-Negative Suppression of Ca(v)2.1 Currents by α(1)2.1 Truncations Requires the Conserved Interaction Domain for β Subunits

Episodic ataxia type 2 (EA2) is an autosomal dominant disorder arising from CACNA1A mutations, which commonly predict heterozygous expression of Ca(v)2.1 calcium channels with truncated α(1)2.1 pore subunits. We hypothesized that α(1)2.1 truncations in EA2 exert dominant-negative effects on the func...

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Bibliographic Details
Main Authors: Raike, Robert S., Kordasiewicz, Holly B., Thompson, Randall M., Gomez, Christopher M.
Format: Artigo
Language:Inglês
Published: 2006
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3236250/
https://ncbi.nlm.nih.gov/pubmed/17161621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mcn.2006.10.011
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