A Common Complement C3 Variant Is Associated with Protection against Wet Age-Related Macular Degeneration in a Japanese Population

BACKGROUND: Genetic variants in the complement component 3 gene (C3) have been shown to be associated with age-related macular degeneration (AMD) in Caucasian populations of European descent. In particular, a nonsynonymous coding variant, rs2230199 (R102G), is presumed to be the most likely causal v...

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Detalhes bibliográficos
Main Authors: Yanagisawa, Suiho, Kondo, Naoshi, Miki, Akiko, Matsumiya, Wataru, Kusuhara, Sentaro, Tsukahara, Yasutomo, Honda, Shigeru, Negi, Akira
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3236234/
https://ncbi.nlm.nih.gov/pubmed/22174912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0028847
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