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Platelet-derived growth factor modulates epidermal growth factor receptors by a mechanism distinct from that of phorbol esters.

Platelet-derived growth factor (PDGF) and phorbol 12-myristate 13-acetate (PMA) decrease high affinity binding of 125I-labeled epidermal growth factor (EGF) and potentiate mitogenesis in BALB/c 3T3 cells, and both have been shown to induce the phosphorylation of the EGF receptor at threonine residue...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Olashaw, N E, O'Keefe, E J, Pledger, W J
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1986
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC323618/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3012534/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.83.11.3834
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