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Direct Entry to Erythronlolides via a Cyclic Bis[Allene]

The complexity and low tractability of antibiotic macrolides pose serious challenges to addressing the problem of resistance through semi- or total synthesis. Here we describe a new strategy, the preparation of a complex, yet tractable, macrocycle, and the transformation of this macrocycle into a ra...

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Detalles Bibliográficos
Autores principales: Liu, Kai, Kim, Hiyun, Ghosh, Partha, Akhmedov, Novruz G., Williams, Lawrence J.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2011
Materias:
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3235949/
https://ncbi.nlm.nih.gov/pubmed/21894913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja207496p
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