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An Environment-dependent Structural Switch Underlies the Regulation of Carnitine Palmitoyltransferase 1A
The enzyme carnitine palmitoyltransferase 1 (CPT1), which is anchored in the outer mitochondrial membrane (OMM), controls the rate-limiting step in fatty acid β-oxidation in mammalian tissues. It is inhibited by malonyl-CoA, the first intermediate of fatty acid synthesis, and it responds to OMM curv...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Biochemistry and Molecular Biology
2011
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3234983/ https://ncbi.nlm.nih.gov/pubmed/21990363 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.306951 |
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