PRL-1 Protein Promotes ERK1/2 and RhoA Protein Activation through a Non-canonical Interaction with the Src Homology 3 Domain of p115 Rho GTPase-activating Protein

Phosphatases of the regenerating liver (PRL) play oncogenic roles in cancer development and metastasis. Although previous studies indicate that PRL-1 promotes cell growth and migration by activating both the ERK1/2 and RhoA pathways, the mechanism by which it activates these signaling events remains...

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Bibliographische Detailangaben
Hauptverfasser: Bai, Yunpeng, Luo, Yong, Liu, Sijiu, Zhang, Lujuan, Shen, Kui, Dong, Yuanshu, Walls, Chad D., Quilliam, Lawrence A., Wells, Clark D., Cao, Youjia, Zhang, Zhong-Yin
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2011
Schlagworte:
Signal Transduction
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3234939/
https://ncbi.nlm.nih.gov/pubmed/22009749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.286302
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