Endogenous Myoglobin in Breast Cancer Is Hypoxia-inducible by Alternative Transcription and Functions to Impair Mitochondrial Activity: A ROLE IN TUMOR SUPPRESSION?

Recently, immunohistochemical analysis of myoglobin (MB) in human breast cancer specimens has revealed a surprisingly widespread expression of MB in this nonmuscle context. The positive correlation with hypoxia-inducible factor 2α (HIF-2α) and carbonic anhydrase IX suggested that oxygen regulates my...

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Bibliografiska uppgifter
Huvudupphovsmän: Kristiansen, Glen, Hu, Junmin, Wichmann, Daniela, Stiehl, Daniel P., Rose, Michael, Gerhardt, Josefine, Bohnert, Annette, ten Haaf, Anette, Moch, Holger, Raleigh, James, Varia, Mahesh A., Subarsky, Patrick, Scandurra, Francesca M., Gnaiger, Erich, Gleixner, Eva, Bicker, Anne, Gassmann, Max, Hankeln, Thomas, Dahl, Edgar, Gorr, Thomas A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2011
Ämnen:
Cell Biology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3234873/
https://ncbi.nlm.nih.gov/pubmed/21930697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.227553
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