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Stabilization of the α2 Isoform of Na,K-ATPase by Mutations in a Phospholipid Binding Pocket
The α2 isoform of Na,K-ATPase plays a crucial role in Ca(2+) handling, muscle contraction, and inotropic effects of cardiac glycosides. Thus, structural, functional, and pharmacological comparisons of α1, α2, and α3 are of great interest. In Pichia pastoris membranes expressing human α1β1, α2β1, and...
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| Main Authors: | , , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Biochemistry and Molecular Biology
2011
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3234826/ https://ncbi.nlm.nih.gov/pubmed/22027833 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.293852 |
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