Contribution of Different Mechanisms to Pancreatic Beta-cell Hyper-secretion in Non-obese Diabetic (NOD) Mice during Pre-diabetes

The development of insulin-dependent diabetes mellitus (IDDM) results from the selective destruction of pancreatic beta-cells. Both humans and spontaneous models of IDDM, such as NOD mice, have an extended pre-diabetic stage. Dynamic changes in beta-cell mass and function during pre-diabetes, such a...

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Main Authors: Liang, Kuo, Du, Wen, Zhu, Wenzhen, Liu, Shuang, Cui, Yeqing, Sun, Haichen, Luo, Bin, Xue, Yanhong, Yang, Lu, Chen, Liangyi, Li, Fei
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3234777/
https://ncbi.nlm.nih.gov/pubmed/21914804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.295931
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