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Proteolytic Cleavage of Chemerin Protein Is Necessary for Activation to the Active Form, Chem157S, Which Functions as a Signaling Molecule in Glioblastoma

Chemerin is a chemoattractant involved in innate and adaptive immunity as well as an adipokine implicated in adipocyte differentiation. Chemerin circulates as an inactive precursor in blood whose bioactivity is closely regulated through proteolytic processing at its C terminus. We developed methodol...

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Hlavní autoři: Yamaguchi, Yasuto, Du, Xiao-Yan, Zhao, Lei, Morser, John, Leung, Lawrence L. K.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3234774/
https://ncbi.nlm.nih.gov/pubmed/21949124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.258921
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