Effect of a Large Dose of Di (2-ethylhexyl) phthalate (DEHP) on Hepatic Peroxisome in Cynomolgus Monkeys (Macaca Fascicularis)

To elucidate the effect of a large dose of di (2-ethylhexyl) phthalate (DEHP), a plasticizer and peroxisome proliferator-activated receptor-α (PPARα) agonist, on hepatic peroxisomes, we orally administered 1,000 mg/kg/day, once daily, to 3 male and 4 female cynomolgus monkeys for 28 days consecutive...

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Hauptverfasser: Satake, Shigeru, Nakamura, Chika, Minamide, Yoshiyuki, Kudo, Shinobu, Maeda, Hiroshi, Chihaya, Yutaka, Kamimura, Yasuhiro, Miyajima, Hiroaki, Sasaki, Jun, Goryo, Masanobu, Okada, Kosuke
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Japanese Society of Toxicologic Pathology 2010
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3234641/
https://ncbi.nlm.nih.gov/pubmed/22272015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1293/tox.23.75
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