Enhanced Urinary Bladder, Liver and Colon Carcinogenesis in Zucker Diabetic Fatty Rats in a Multiorgan Carcinogenesis Bioassay: Evidence for Mechanisms Involving Activation of PI3K Signaling and Impairment of p53 on Urinary Bladder Carcinogenesis

In the present study, modifying effects of diabetes on carcinogenesis induced in type 2 diabetes mellitus model Zucker diabetic fatty (ZDF) rats were investigated using a multiorgan carcinogenesis bioassay. Our re sults demonstrated enhancement of urinary bladder, colon and liver carcinogenesis in Z...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Ishii, Naomi, Wei, Min, Kakehashi, Anna, Doi, Kenichiro, Yamano, Shotaro, Inaba, Masaaki, Wanibuchi, Hideki
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The Japanese Society of Toxicologic Pathology 2011
Pynciau:
Original
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3234622/
https://ncbi.nlm.nih.gov/pubmed/22272041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1293/tox.24.25
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