Cyclooxygenase 2 and Prostaglandin E2 are not Involved in N-Nitrosodiethylamine-Initiated Early Rat Hepatocarcinogenesis

The present study was undertaken to investigate the effect of dietary supplementation with nimesulide or eugenol on N-nitrosodiethylamine (DEN)-initiated early hepatocarcinogenesis in F344 male rats. Both compounds did not alter the expression of cytochrome P450 (CYP) 2E1, the enzyme that plays a ma...

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Autors principals: Said, Mahmoud M., Ogawa, Kumiko, Pitchakarn, Pornsiri, Takahashi, Satoru, Asamoto, Makoto, Shirai, Tomoyuki
Format: Artigo
Idioma:Inglês
Publicat: The Japanese Society of Toxicologic Pathology 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3234601/
https://ncbi.nlm.nih.gov/pubmed/22272001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1293/tox.22.263
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